Fresh analysis reveals that patients who discontinue new GLP-1 drugs like Wegovy and Mounjaro may regain shed pounds much more quickly than those who end traditional diet and exercise programs.
Research printed in a leading health publication shows that while overweight individuals often shed about a fifth of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month after stopping.
"Users buying such medications must be aware of the danger of rapid weight regain when the therapy ends," warns expert Dr. Susan Jebb.
That rate of recovery means a return to starting mass within about one and a half years.
Weighing Approaches
The analysis, which examined 37 of trials involving thousands of participants, compared the effects of the injectable medications with conventional dieting.
Researchers emphasize that people who lose weight through dieting generally experience a more gradual weight regain—perhaps 0.1 kg a month—after stopping.
The Reason for the Fast Regain
Experts suggest the way of the injections explains the heightened regain.
These medications mimic a body's own chemical called GLP-1, which moderates appetite.
"Artificially providing the hormone concentrations several times higher than the body's typical production may cause the system to produce less of its own natural hormone, and may also lessen sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication means hunger is uncontrolled, making excessive eating a significant risk."
A Lifelong Issue?
The NHS suggest the injections for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Professionals contend that, considering the likelihood of relapse, the therapy might need to be life-long.
This opinion is supported by drug manufacturers, who note that the findings "underscore the persistent nature of obesity," akin to managing conditions like hypertension.
User Testimonies
People who have stopped the jabs describe a intense return of cravings.
"It felt as if a switch flipping and I was suddenly ravenous," said a patient.
The struggle is compounded if patients have not adopted permanent dietary or behavioural changes during therapy.
Significant Use
Recent estimates suggest that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is greater among females compared to men.
- The middle-aged demographic shows the greatest level of interest.
- Many access the drugs through private healthcare rather than public health services.
In conclusion, experts caution that while these medications are potent tools for weight loss, they are not a magic cure and maintained weight loss likely depends on integrated behavioural changes.
